Evidence supporting the use of: Quercetin
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a plant flavonoid found in many fruits and vegetables and is commonly investigated for its antioxidant and anti-inflammatory properties. In the context of cirrhosis of the liver, the use of quercetin is justified primarily by preclinical scientific evidence rather than by historical or traditional use. Several animal studies have demonstrated that quercetin can reduce oxidative stress, inhibit hepatic stellate cell activation (a key event in liver fibrosis), and attenuate liver inflammation and fibrosis in models of chemically induced liver injury. For example, studies in rats treated with carbon tetrachloride (CCl4), a compound that induces liver fibrosis, have shown that quercetin administration can decrease markers of liver damage and collagen deposition. These effects are thought to arise from quercetin’s ability to modulate signaling pathways associated with inflammation, apoptosis, and fibrogenesis.

However, clinical evidence in humans is lacking. There are currently no large, high-quality clinical trials demonstrating that quercetin supplementation benefits patients with cirrhosis or can reverse established fibrosis. Most recommendations for its use are based on laboratory or animal data, and its efficacy and safety profile in human patients with advanced liver disease remain uncertain. In summary, while there is scientific interest and preclinical support for quercetin’s potential in liver disease, its use for cirrhosis is not currently validated by robust clinical evidence.

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