Evidence supporting the use of: Vitamin D
For the body system: Circulatory System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D has scientific evidence supporting its role in the circulatory system, particularly regarding cardiovascular health. Vitamin D receptors are present in many cell types, including those in the heart and blood vessels, indicating its potential influence on these tissues. Epidemiological studies have identified an association between low vitamin D levels and increased risk of hypertension, heart failure, and other cardiovascular diseases. Mechanistically, vitamin D is thought to modulate the renin-angiotensin-aldosterone system, reduce inflammation, and improve endothelial function, all of which are relevant to circulatory health.

However, randomized controlled trials (RCTs) investigating vitamin D supplementation for the prevention or treatment of cardiovascular disease have shown mixed results. Some studies report modest benefits, particularly in individuals with significant vitamin D deficiency, while others find no significant effect. For example, the VITAL study (2019) found no significant reduction in major cardiovascular events with vitamin D supplementation in the general population. Meta-analyses suggest that any potential benefit may be limited to those with very low baseline vitamin D levels.

In summary, while there is mechanistic and observational evidence suggesting a role for vitamin D in circulatory system health, clinical trial data are inconclusive, leading to a moderate rating of the strength of evidence supporting its use for this purpose.

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