Electrolyte blends, typically containing sodium, potassium, calcium, magnesium, chloride, and sometimes phosphate, are scientifically validated in their role supporting the circulatory system. Electrolytes are essential minerals that help regulate fluid balance, nerve signaling, and muscle contraction, all of which are critical for normal cardiovascular function. Sodium and potassium, in particular, are crucial for maintaining proper blood pressure and heart rhythm. When electrolyte levels are imbalanced—due to dehydration, strenuous exercise, illness, or certain medications—circulatory problems such as arrhythmias, low blood pressure, or even cardiac arrest can occur.

Numerous clinical studies have demonstrated that rehydration with electrolyte solutions is more effective than water alone for restoring circulatory stability after dehydration. The World Health Organization's oral rehydration solutions, for example, are a cornerstone treatment for circulatory collapse due to severe dehydration. While the use of proprietary blends in supplements is widespread, the underlying rationale is based on well-established physiological roles of these minerals. However, most scientific evidence pertains to acute correction of deficiencies or imbalances, rather than routine supplementation in healthy individuals. Overall, the use of electrolyte blends for supporting circulatory health is supported by substantial scientific evidence, particularly in contexts of increased need or loss.