Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pine bark extract, particularly standardized forms like Pycnogenol® (derived from Pinus pinaster), has scientific evidence supporting its use for improving circulation, including cerebral (brain) blood flow. The active components in pine bark extract are oligomeric proanthocyanidins (OPCs), potent antioxidants that help to protect blood vessels and improve endothelial function. Several clinical studies have investigated pine bark extract’s effects on vascular health. For instance, some research has shown that supplementation can enhance microcirculation, decrease blood viscosity, and improve cognitive function in elderly subjects, likely by increasing cerebral blood flow. A 2012 randomized controlled trial found that older adults taking Pycnogenol® demonstrated improvements in attention, memory, and executive function, possibly due to enhanced cerebral perfusion. The mechanisms proposed include reduction of oxidative stress, strengthening of capillaries, and promotion of nitric oxide synthesis, which relaxes blood vessels and improves blood flow. However, while results are promising, most studies are small or short-term, and more large-scale, independent trials are needed to confirm efficacy and determine optimal dosing. Overall, the use of pine bark extract for supporting brain circulation is supported by preliminary scientific evidence, with a moderate rating of 3, reflecting promising but not yet conclusive data.

More about pine bark
More about Circulation (to the brain)

Other ingredients used for Circulation (to the brain)

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Products containing pine bark

Nature's Sunshine High Potency Grapine
Nature's Sunshine Grapine With Protectors (SynerPro)