Evidence supporting the use of: Grape
For the health condition: Circulation (to the brain)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Grape, particularly in the form of grape seed extract and red or purple grape polyphenols, has been investigated for its potential benefits on circulation, including cerebral (brain) circulation. The scientific interest in grape's vascular effects centers on its high content of flavonoids and other polyphenolic compounds, such as resveratrol and proanthocyanidins, which possess antioxidant and vasodilatory properties. Several clinical and preclinical studies suggest that these compounds can improve endothelial function, reduce oxidative stress, and enhance blood flow by promoting nitric oxide release and inhibiting platelet aggregation.

Specific to cerebral circulation, some small clinical trials and animal studies indicate that grape polyphenols may improve cognitive function and cerebral blood flow, particularly in older adults or those at risk for cognitive decline. For example, studies have shown that supplementation with grape seed extract or resveratrol can lead to improved measures of cerebral perfusion and cognitive performance. However, the evidence is not yet robust, with studies often limited by small sample sizes, short durations, and variability in dosages and formulations.

Overall, while the use of grape and its extracts for supporting circulation to the brain is supported by plausible mechanisms and preliminary scientific evidence, more large-scale, well-controlled human studies are needed. Accordingly, the evidence is moderate (rated 3 out of 5), reflecting promising but not definitive scientific validation.

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