Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgolide C is one of the terpene lactones found in Ginkgo biloba extract, a traditional herbal remedy often used to support cognitive function and cerebral circulation. Scientific studies on Ginkgo biloba as a whole suggest some potential for improving cerebral blood flow, likely through multiple mechanisms such as anti-platelet aggregation and vasodilation. Ginkgolide C, specifically, is known as a potent antagonist of platelet-activating factor (PAF), which implies it may help prevent microvascular thrombosis and improve microcirculation in the brain.

However, most clinical research has been conducted using standardized Ginkgo biloba extracts containing a mixture of ginkgolides (A, B, C, etc.) and flavonoids, rather than isolated Ginkgolide C. There are limited direct studies on Ginkgolide C alone in relation to cerebral circulation. The evidence supporting Ginkgo biloba extracts in improving cognitive function and cerebral blood flow is mixed, with some meta-analyses showing modest benefit in specific populations (e.g., patients with dementia or cognitive impairment), while others find limited or no significant effect.

In summary, while the use of Ginkgo biloba for supporting brain circulation has some scientific backing, the evidence for isolated Ginkgolide C is limited. Most of the positive findings come from studies on whole extracts, and the clinical significance remains uncertain. Therefore, the evidence rating is 2 out of 5.

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