Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthocyanosides, which are flavonoid compounds found in various fruits such as bilberry and blueberry, have been investigated for their potential to support circulation, particularly to the brain. Scientific interest in these compounds stems from their antioxidant, anti-inflammatory, and vasoprotective properties. Several clinical and preclinical studies have suggested that anthocyanosides can improve microcirculation, enhance endothelial function, and increase capillary resistance, which may support cerebral blood flow.

For example, bilberry extract (rich in anthocyanosides) has been used in Europe to treat vascular disorders, and some human studies have indicated improvements in symptoms related to venous insufficiency and microvascular complications. Preliminary research also suggests that anthocyanoside supplementation may improve cognitive performance in older adults, potentially through improved cerebral blood flow, although results are mixed and more large-scale, well-controlled trials are needed.

Despite promising mechanisms and some supportive clinical data, the overall quality and quantity of evidence specifically linking anthocyanosides to improved circulation in the brain is moderate. Systematic reviews highlight the need for more rigorous, long-term studies to confirm cognitive and circulatory benefits. In summary, while there is a scientific rationale and some supporting data, the evidence is not yet robust, justifying a moderate evidence score.

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