Evidence supporting the use of: Vitamin B3 (mixed)
For the health condition: Circulation (poor)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B3, also known as niacin, has scientific validation for its use in supporting poor circulation, particularly in the context of peripheral vascular diseases such as peripheral artery disease (PAD). Niacin is well-known for its lipid-modifying effects, including decreasing LDL cholesterol, lowering triglycerides, and raising HDL cholesterol. These effects can help improve vascular health and may indirectly benefit circulation. Additionally, niacin causes peripheral vasodilation, which leads to the characteristic "niacin flush"—a temporary reddening of the skin due to increased blood flow. This vasodilatory property has led to its use in attempts to improve peripheral circulation.
Clinical evidence specifically supporting niacin for "poor circulation" outside of lipid disorders is moderate. Some studies have observed improved blood flow and endothelial function in patients taking niacin, but these are often secondary outcomes in trials primarily targeting cholesterol levels. There is limited direct evidence for niacin as a primary treatment for circulation problems unrelated to dyslipidemia. The use of niacin for circulation is more strongly supported in cases where poor circulation is secondary to atherosclerosis or lipid abnormalities, rather than in cases of idiopathic or non-atherosclerotic circulatory issues.
In summary, there is scientific rationale and some moderate clinical evidence backing the use of vitamin B3 (niacin) to support circulation, especially when poor circulation is associated with vascular disease and abnormal blood lipids. However, it is not a first-line treatment for circulation issues in the absence of these conditions.
Other ingredients used for Circulation (poor)
acetyl l-carnitineajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
lingusticum wallichii
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
zanthoxylum
birch
polyphenols
purslane
yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Arjuna
Arginine Alpha Ketoglutarate
Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Asteracea
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
Atractylone
Bishop's Weed
Butea monosperma
Black galingale
berry
Bur-Reed
Bioflavonoids
Bee products
Buddha's Hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
Borneol
Coumarin
Centella triterpenes
Chinese Silkvine
Cinnamomum
Chinese Mountain Ant
Carqueja
Calycosin
Capsinoids
Codonopsis
Capillary Artemisia
Cyanidin
Curcuminoid
Citrus
Capsaicin
Catecholamine
Cowherb
Curcumen
Centella asiatica
Coca
Chocolate
Curcuma
Chestnut
Cinnamaldehyde
Costus
Carthamus
cola nut
Currant
Diallyl sulfide
Diosmin
Dismutase
Danshen
Dong Quai
Date
Diosmetin
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Elk antler
Eicosapentaenoic Acid
Ethylenediaminetetraacetic acid (EDTA)
Echium
Garlic
Mustard
Mistletoe
Pistachio
Sumac
Sweet Orange alcohol
yohimbine
Zucchini