Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Phthalides are a group of bioactive compounds found primarily in plants within the Apiaceae family, such as celery (Apium graveolens) and Ligusticum species (e.g., Ligusticum chuanxiong, a key herb in traditional Chinese medicine). The use of phthalide-rich herbs, particularly in traditional Chinese medicine, has a long history for promoting blood circulation and addressing conditions associated with "blood stasis," which can be interpreted as poor circulation. The most notable phthalide, ligustilide, is thought to contribute to these effects. Historical texts and traditional herbal formulas often include these plants for vascular health, menstrual disorders, and circulatory support.

From a scientific standpoint, there are some preliminary studies (mostly in vitro and animal models) indicating that phthalides may exert vasodilatory effects, inhibit platelet aggregation, and improve microcirculation. However, robust clinical trials in humans are lacking. Thus, while there are plausible pharmacological mechanisms, the primary justification for using phthalides to support poor circulation remains rooted in tradition, not in modern scientific validation. Therefore, the evidence rating is moderate (2), reflecting a strong traditional basis with limited but intriguing scientific support that does not yet rise to a high standard of clinical proof.

More about Phthalides
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Other ingredients used for Circulation (poor)

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