Evidence supporting the use of: Peptide (bonito)
For the health condition: Circulation (poor)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Peptide (bonito), specifically referring to peptides derived from bonito fish (a species of tuna), has been investigated for its effects on circulation, particularly in relation to blood pressure and vascular health. Scientific studies, mostly from Japan, have demonstrated that certain bonito-derived peptides can act as ACE (angiotensin-converting enzyme) inhibitors, which may help to lower blood pressure and improve endothelial function. A number of clinical trials have evaluated bonito peptide supplementation (often in the form of hydrolyzed bonito extract) and reported modest but statistically significant reductions in systolic and diastolic blood pressure in people with mild hypertension or prehypertension.
The mechanism of action is similar to pharmaceutical ACE inhibitors, where inhibition of this enzyme leads to vasodilation and improved blood flow. These effects may support overall circulation, though the magnitude of benefit is generally less than that of prescription medications. Some studies also suggest potential improvements in markers of arterial stiffness and blood vessel function, but evidence for broader circulatory benefits beyond blood pressure is limited.
Overall, while the evidence base is not extremely large or robust (hence the rating of 3), there is scientific validation from controlled trials and mechanistic studies supporting the use of bonito peptides for improving aspects of poor circulation related to hypertension. However, more high-quality, large-scale studies are needed to better define the clinical significance and safety profile of long-term use.
Other ingredients used for Circulation (poor)
acetyl l-carnitineajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
lingusticum wallichii
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
zanthoxylum
birch
polyphenols
purslane
yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Arjuna
Arginine Alpha Ketoglutarate
Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Asteracea
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
Atractylone
Bishop's Weed
Butea monosperma
Black galingale
berry
Bur-Reed
Bioflavonoids
Bee products
Buddha's Hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
Borneol
Coumarin
Centella triterpenes
Chinese Silkvine
Cinnamomum
Chinese Mountain Ant
Carqueja
Calycosin
Capsinoids
Codonopsis
Capillary Artemisia
Cyanidin
Curcuminoid
Citrus
Capsaicin
Catecholamine
Cowherb
Curcumen
Centella asiatica
Coca
Chocolate
Curcuma
Chestnut
Cinnamaldehyde
Costus
Carthamus
cola nut
Currant
Diallyl sulfide
Diosmin
Dismutase
Danshen
Dong Quai
Date
Diosmetin
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
epicatechin
Eupolyphaga sinensis
Elk antler
Evodiamine
Eicosapentaenoic Acid
Essential Oil Blend
Ephedrine
Ethylenediaminetetraacetic acid (EDTA)
European-Five Finger Grass
Echium
Fruit
Flavonoids
Fo-Ti
Flat-stem milk-vetch
Fatty acids
Flavanones
Fagopyrum
Flavoglycosides
Flavans
Forskolin
Flavonones
Flavanols
Flavones
Ginsenosides
Glycoside
Garlic
Ginkgo Flavone Glycoside
Mustard
Mistletoe
Pistachio
Sumac
Sweet Orange alcohol
yohimbine
Zucchini
Other health conditions supported by Peptide (bonito)
ArthritisBlood Clots (prevention of)
Cholesterol (high)
Circulation (poor)
Fatigue
Hypertension
Inflammation
Triglycerides (high)
