Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacinamide (vitamin B3) is chemically related to niacin (nicotinic acid), though their pharmacological effects differ. While niacin is more widely recognized for its vasodilatory properties—producing skin flushing and being used in high doses to improve lipid profiles and peripheral circulation—niacinamide does not cause significant vasodilation at normal supplemental doses. However, both forms are precursors to NAD+ and NADP+, essential coenzymes in cellular metabolism, including pathways that affect vascular health and energy production. The use of niacinamide for circulation is supported by some scientific rationale, mainly extrapolated from studies on niacin. Niacin has demonstrated efficacy in improving peripheral vascular circulation, particularly in conditions like peripheral artery disease (PAD) and intermittent claudication. However, the evidence for niacinamide is less robust. Some small studies and case reports suggest that niacinamide may help in certain microvascular disorders—such as Raynaud's phenomenon or pellagra—where deficiency of vitamin B3 impairs vascular function. In pellagra, vascular symptoms resolve with vitamin B3 supplementation, indicating a role in vascular health when deficiency is present. Overall, while niacinamide might support circulation indirectly by correcting deficiency and supporting endothelial function, its direct vasodilatory effects are minimal compared to niacin. Therefore, scientific evidence supports its use for circulation to a moderate extent (rated 3/5), but it is not the preferred form for addressing poor circulation unless B3 deficiency is implicated.

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