Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-citrulline is an amino acid that is used to support circulation, particularly in individuals with poor blood flow. Its use is primarily supported by scientific evidence. L-citrulline acts as a precursor to L-arginine, which is then converted into nitric oxide (NO) in the body. Nitric oxide is a key signaling molecule that relaxes blood vessels and improves endothelial function, leading to vasodilation and enhanced blood flow.

Several clinical studies have investigated the effects of L-citrulline supplementation on vascular health. Research demonstrates that L-citrulline supplementation can increase plasma L-arginine levels more effectively than taking L-arginine directly, due to better absorption and metabolism. Studies in both healthy individuals and those with conditions like hypertension or peripheral arterial disease have shown that L-citrulline can improve vascular function, reduce blood pressure modestly, and enhance exercise performance by improving oxygen delivery to muscles.

While most studies are small and of short duration, the mechanisms are well-understood and findings are consistent: increased nitric oxide production leads to improved endothelial function and circulation. However, large-scale, long-term trials are still limited, and the evidence is stronger for mild to moderate improvements rather than treatment of severe circulatory problems. Thus, the strength of evidence is rated as moderate (3/5), reflecting promising but not definitive support for its use in supporting circulation.

More about l-citrulline
More about Circulation (poor)

Other ingredients used for Circulation (poor)

Other health conditions supported by l-citrulline

Products containing l-citrulline

Nature's Sunshine Solstic Cardio