Evidence supporting the use of: Icariin
For the health condition: Circulation (poor)
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Icariin is a flavonoid compound found in the herb Epimedium, commonly referred to as "Horny Goat Weed" in traditional Chinese medicine (TCM). Its use for improving circulation and treating conditions related to poor blood flow is rooted primarily in traditional practices rather than strong scientific validation. In TCM, Epimedium is considered to "tonify the kidney" and "invigorate the yang," with secondary effects believed to include enhanced blood flow and improved vitality. Historical texts and herbal compendia describe its use for conditions such as fatigue, weakness, and circulatory issues.
Modern scientific studies on icariin focus mainly on its potential roles in erectile dysfunction and cardiovascular health, but robust human clinical evidence is limited. Some preclinical studies in animals and in vitro have demonstrated that icariin exhibits vasodilatory effects, possibly through the enhancement of nitric oxide production and inhibition of phosphodiesterase-5 (PDE5), which could theoretically improve circulation. However, these findings are preliminary, and there is a lack of large-scale, high-quality clinical trials in humans specifically addressing its efficacy for poor circulation. Thus, while icariin is used for circulation in traditional contexts, the current scientific evidence supporting this use is modest.
Other ingredients used for Circulation (poor)
acetyl l-carnitineajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
lingusticum wallichii
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
zanthoxylum
birch
polyphenols
purslane
yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Arjuna
Arginine Alpha Ketoglutarate
Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Asteracea
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
Atractylone
Bishop's Weed
Butea monosperma
Black galingale
berry
Bur-Reed
Bioflavonoids
Bee products
Buddha's Hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
Borneol
Coumarin
Centella triterpenes
Chinese Silkvine
Cinnamomum
Chinese Mountain Ant
Carqueja
Calycosin
Capsinoids
Codonopsis
Capillary Artemisia
Cyanidin
Curcuminoid
Citrus
Capsaicin
Catecholamine
Cowherb
Curcumen
Centella asiatica
Coca
Chocolate
Curcuma
Chestnut
Cinnamaldehyde
Costus
Carthamus
cola nut
Currant
Diallyl sulfide
Diosmin
Dismutase
Danshen
Dong Quai
Date
Diosmetin
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Elk antler
Eicosapentaenoic Acid
Ethylenediaminetetraacetic acid (EDTA)
Echium
Garlic
Mustard
Mistletoe
Pistachio
Sumac
Sweet Orange alcohol
yohimbine
Zucchini
Other health conditions supported by icariin
Aging (prevention)Alzheimer's Disease
Cancer (natural therapy for)
Cancer (prevention)
Cardiovascular Disease
Circulation (poor)
Depression
Diabetes
Erectile Dysfunction
Fatigue
Hypertension
Inflammation
Memory and Brain Function
Osteoporosis
Parkinson's Disease
Sex Drive (low)
Testosterone (low)