Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Diosmin is a flavonoid compound primarily found in citrus fruits and is widely used in Europe and other parts of the world for the treatment of various circulatory disorders, particularly chronic venous insufficiency (CVI), hemorrhoids, and varicose veins. There is substantial scientific evidence supporting its effectiveness in improving poor circulation, especially in the lower limbs.

Multiple randomized controlled trials and meta-analyses have shown that diosmin (often combined with hesperidin) can reduce symptoms such as leg swelling (edema), pain, heaviness, and cramps associated with CVI. Diosmin is thought to work by strengthening blood vessel walls, reducing inflammation, and improving the tone of veins, which facilitates better blood return to the heart. Clinical guidelines in several European countries recommend its use as a first-line treatment for venous insufficiency and hemorrhoidal disease.

The 2018 Cochrane Review on phlebotonics (including diosmin) concluded that these compounds offer modest but significant symptomatic relief for people with CVI. Side effects are generally mild and rare, such as gastrointestinal discomfort.

While diosmin is less commonly prescribed in North America, its use is well-established and evidence-based in other regions. Overall, the scientific literature strongly supports diosmin’s role in supporting and treating conditions related to poor circulation.

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Other ingredients used for Circulation (poor)

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