Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Circulation (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant found in most human cells, where it plays a key role in mitochondrial energy production. Its use for supporting or treating poor circulation is based on both its physiological role and several clinical studies, though the evidence is moderate rather than robust. CoQ10 has been studied primarily in the context of cardiovascular health, particularly in conditions such as heart failure, hypertension, and endothelial dysfunction—all of which are related to circulatory health. Some studies suggest that CoQ10 supplementation can improve endothelial function, which is crucial for healthy blood flow, by enhancing nitric oxide availability and reducing oxidative stress in blood vessels. Meta-analyses have demonstrated modest improvements in blood pressure and vascular function with CoQ10 supplementation. However, direct evidence for its efficacy in treating "poor circulation" as a generalized condition is limited, as most research focuses on specific cardiovascular diseases. The conventional use of CoQ10 for circulation is therefore extrapolated from its effects on cardiovascular endpoints. While CoQ10 is generally well-tolerated and considered safe, more high-quality, targeted studies are needed to establish its effectiveness for poor circulation specifically. In summary, CoQ10’s use for circulation is scientifically plausible and supported by some clinical research, but the strength of evidence is moderate, meriting a rating of 2 out of 5.

More about coenzyme Q10 (CoQ10)
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Other ingredients used for Circulation (poor)

acetyl l-carnitine
ajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
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punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
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prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
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zanthoxylum
birch
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herbal blend (proprietary)
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enzymes blend (proprietary)
cayenne pepper
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Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Asteracea
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
Atractylone
Bishop's Weed
Butea monosperma
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Bur-Reed
Bioflavonoids
Bee products
Buddha's Hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
Borneol
Coumarin
Centella triterpenes
Chinese Silkvine
Cinnamomum
Chinese Mountain Ant
Carqueja
Calycosin
Capsinoids
Codonopsis
Capillary Artemisia
Cyanidin
Curcuminoid
Citrus
Capsaicin
Catecholamine
Cowherb
Curcumen
Centella asiatica
Coca
Chocolate
Curcuma
Chestnut
Cinnamaldehyde
Costus
Carthamus
cola nut
Currant
Diallyl sulfide
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Dismutase
Danshen
Dong Quai
Date
Diosmetin
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epicatechin
Elk antler
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Ephedrine
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Mustard
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Sumac
Sweet Orange alcohol
yohimbine
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