Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrulline silicate is a combination ingredient that releases both L-citrulline and silicon. L-citrulline is a naturally occurring amino acid involved in the urea cycle and is known to increase nitric oxide (NO) production through its conversion to L-arginine. Increased NO levels can promote vasodilation, potentially improving blood flow and circulation. There is some scientific evidence supporting L-citrulline supplementation for improving endothelial function and circulation, particularly in populations with endothelial dysfunction or mild circulatory impairment. However, most of the research has been conducted with L-citrulline or L-citrulline malate, not specifically citrulline silicate.

Silicon, the other component of citrulline silicate, has some evidence for supporting vascular health, but its effect on circulation in the context of this compound is not well studied.

A few small clinical trials and preclinical studies suggest that citrulline silicate can acutely increase plasma arginine and NO levels, and may enhance endothelial-dependent vasodilation. However, robust, long-term clinical evidence for the use of citrulline silicate specifically in the treatment of poor circulation is lacking. Thus, while the mechanistic rationale is sound and there is some preliminary scientific support, the overall quality and quantity of evidence are moderate at best, meriting a rating of 2 out of 5.

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