Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Arginine nitrate is used to support circulation primarily based on scientific principles, though direct clinical evidence is moderate. Arginine is an amino acid that is a known precursor to nitric oxide (NO), a molecule that causes vasodilation and improves blood flow. Nitrate, similarly, can be converted in the body to nitric oxide via the nitrate-nitrite-NO pathway. The combination of arginine and nitrate theoretically enhances NO production through both pathways, potentially offering greater circulatory benefits than either alone.

Studies on L-arginine alone have shown improvements in endothelial function and vasodilation, especially in populations with compromised vascular health. Dietary nitrates (from sources like beetroot) are also well established in the literature for their ability to enhance NO levels and improve circulation and blood pressure. However, specific studies on arginine nitrate as a compound are limited, with most evidence being extrapolated from studies of its individual components.

Therefore, while there is a biological rationale and some supportive clinical data for the use of arginine and nitrate to improve circulation, direct clinical trials using arginine nitrate are lacking. The evidence level is rated a 3 because there is moderate support from related research, but more direct, high-quality studies on the combined ingredient are needed to confirm its efficacy for poor circulation.

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Other ingredients used for Circulation (poor)

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