Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthocyanidins, a class of flavonoids found in berries, red grapes, and other colorful fruits and vegetables, are used to support poor circulation based largely on scientific evidence. Several studies have investigated the effects of anthocyanidins and their glycoside forms, anthocyanins, on vascular health. Experimental and clinical data suggest that anthocyanidins have vasoprotective properties, such as improving endothelial function, reducing oxidative stress, and enhancing capillary strength and microcirculation.

For example, randomized controlled trials (RCTs) and meta-analyses have demonstrated that supplementation with anthocyanin-rich extracts can improve endothelial-dependent vasodilation and may lower blood pressure in both healthy individuals and those with cardiovascular risk factors. These effects are attributed to enhanced nitric oxide production and decreased vascular inflammation. A 2019 meta-analysis in Critical Reviews in Food Science and Nutrition found significant improvements in vascular function with anthocyanin supplementation.

However, while there is consistent evidence for positive vascular effects, the direct clinical impact on “poor circulation” as a defined syndrome (such as in peripheral arterial disease or chronic venous insufficiency) is less robust, with most studies focusing on surrogate endpoints rather than clinical outcomes. Overall, anthocyanidins are justified for circulation support with moderate scientific evidence, particularly for vascular health and endothelial function, but more research is needed for direct therapeutic claims.

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