Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Amino acid blends or complexes are sometimes used to support circulation, as certain amino acids play roles in vascular health. The primary scientific rationale centers on amino acids such as L-arginine and L-citrulline, which are precursors for nitric oxide (NO) synthesis. Nitric oxide is a signaling molecule that promotes vasodilation, thereby enhancing blood flow. Clinical studies have shown that supplementation with L-arginine or L-citrulline may improve endothelial function and increase blood flow, particularly in individuals with endothelial dysfunction or peripheral arterial disease. For example, some randomized controlled trials have demonstrated improvement in walking distance for individuals with peripheral artery disease after L-arginine supplementation. However, not all studies show consistent benefits, and the magnitude of effect is often modest.

Blends or complexes of amino acids may also include other amino acids that support vascular health indirectly, such as taurine or glycine, but the evidence for their direct effect on circulation is less robust. Overall, the use of amino acid blends for poor circulation has a scientific basis, primarily related to their influence on nitric oxide production and vascular tone. However, the clinical evidence is moderate (rated 3/5), with more high-quality research needed to establish efficacy and optimal formulations. The use is not primarily based on tradition, but rather on mechanistic and some clinical evidence.

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