Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Atractylone is a sesquiterpene compound found in Atractylodes species, especially Atractylodes macrocephala, a key herb in traditional Chinese medicine (TCM). The use of Atractylone or its source plants to support or treat Chronic Obstructive Pulmonary Disease (COPD) is primarily justified by traditional medical practice, not by robust modern scientific evidence. In TCM, Atractylodes is included in various herbal formulas to tonify the spleen, resolve dampness, and support lung function, which can be indirectly associated with symptom management in COPD. Some preclinical studies (in vitro and animal models) have suggested anti-inflammatory and immunomodulatory properties for Atractylone or its extracts, which could theoretically benefit respiratory conditions. However, direct evidence from clinical trials specifically addressing Atractylone's effectiveness in COPD patients is lacking. The rating of 2 reflects the presence of historical/traditional use and limited preclinical data, but the absence of high-quality clinical research for this specific indication. Therefore, while Atractylone-containing herbs are used in traditional settings for respiratory support, the scientific validation for their use in COPD remains limited.

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