Evidence supporting the use of: Astragaloside
For the health condition: Chronic Obstructive Pulmonary Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astragaloside, particularly astragaloside IV, is a bioactive saponin component derived from the traditional Chinese medicinal herb Astragalus membranaceus. While Astragalus has a long tradition of use in Chinese medicine for respiratory and immune-related conditions, the specific use of astragaloside for Chronic Obstructive Pulmonary Disease (COPD) is supported by a growing, though still limited, body of scientific evidence.

Preclinical studies have shown that astragaloside IV can exert protective effects in animal models of COPD. These effects are believed to be due to its anti-inflammatory, anti-oxidative, and anti-apoptotic properties. For instance, several rodent studies have demonstrated that astragaloside IV can decrease inflammatory cytokines (e.g., TNF-α, IL-6), reduce oxidative stress markers, and improve lung histopathology following exposure to cigarette smoke or other irritants that induce COPD-like pathology.

Some mechanistic research suggests that astragaloside IV may modulate NF-κB signaling pathways and improve mitochondrial function, both of which are implicated in the pathogenesis of COPD. However, direct clinical evidence in humans is lacking. So far, there are only a few small-scale clinical trials or case reports, and these are not sufficient to draw strong conclusions about efficacy or safety in the management of COPD.

In summary, the use of astragaloside for COPD is supported by preliminary scientific evidence from animal and cell studies, but robust clinical data in humans are still needed. Thus, the evidence rating is a 2 out of 5.

More about Astragaloside
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Products containing Astragaloside

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