Evidence supporting the use of: Morus
For the health condition: Cholesterol (low)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Morus, commonly known as mulberry, particularly the leaves of Morus alba (white mulberry), has been investigated for its potential effects on cholesterol levels. Several animal studies and a growing number of human clinical trials suggest that extracts from mulberry leaves may help reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides, while sometimes increasing high-density lipoprotein (HDL) cholesterol. The primary bioactive components responsible for these effects are thought to be flavonoids, especially rutin and quercetin, as well as 1-deoxynojirimycin (DNJ), which is known for its role in carbohydrate metabolism but may also influence lipid profiles. For example, a 2012 randomized, placebo-controlled trial published in Phytotherapy Research found that adults with mild dyslipidemia who consumed mulberry leaf supplements for 12 weeks experienced significant reductions in serum total cholesterol and LDL cholesterol. Other studies in animals have shown similar lipid-lowering effects, possibly by modulating hepatic lipid metabolism and increasing fecal cholesterol excretion. While the evidence is promising, most clinical trials to date are small and relatively short in duration. Therefore, while there is scientific validation for the use of Morus in lowering cholesterol (when high), the evidence base is not yet robust enough to warrant a very high confidence rating. More large-scale, long-term human studies are needed to fully establish efficacy and safety.

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