Evidence supporting the use of: Grape
For the health condition: Cholesterol (low)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Grapes, particularly in the form of grape seed extract or red/purple grape juice, have been studied for their potential effects on cholesterol levels. Scientific evidence suggests that certain compounds in grapes, such as polyphenols (notably resveratrol and proanthocyanidins), may have lipid-lowering properties. Several clinical trials and meta-analyses have evaluated the impact of grape products on cholesterol levels, with some studies demonstrating modest reductions in total cholesterol and LDL ("bad") cholesterol, as well as increases in HDL ("good") cholesterol. The proposed mechanisms include antioxidant effects, improved endothelial function, and inhibition of cholesterol absorption.

However, the magnitude of these effects is generally small to moderate, and results are somewhat inconsistent across different studies, which is why the evidence rating is not higher. The use of grape products for low cholesterol (hypocholesterolemia), specifically, is less well supported, as most research focuses on lowering high cholesterol rather than treating low cholesterol. There is little to no evidence suggesting that grape or grape-derived products are used to increase cholesterol levels in cases of abnormally low cholesterol. Instead, their primary utility in this area is adjunctive support in the management of elevated cholesterol.

In summary, scientific evidence supports the use of grapes to help lower high cholesterol, but not to treat low cholesterol. Grapes are not traditionally used for this purpose, and they are not a primary therapy for cholesterol disorders, but may offer some supportive cardiovascular benefits.

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