Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kaempferide is a natural flavonoid compound found in various plants, including Kaempferia galanga and other medicinal herbs. There is some scientific evidence suggesting that kaempferide may have lipid-lowering properties. Preclinical studies, mainly in animal models, have demonstrated that kaempferide administration can reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels. For example, a study in rats fed a high-fat diet showed that kaempferide supplementation significantly lowered serum cholesterol and improved antioxidant status. The proposed mechanisms include inhibition of cholesterol absorption, enhancement of cholesterol excretion, and modulation of lipid metabolism pathways, possibly through antioxidant and anti-inflammatory effects. However, it is important to note that the evidence is limited primarily to animal studies and in vitro experiments. There are no robust clinical trials in humans that directly assess the efficacy of kaempferide in treating or supporting high cholesterol. Additionally, the exact dosage, safety profile, and long-term effects in humans remain unclear. While the preclinical data are promising and provide a rationale for further research, current evidence does not support the routine use of kaempferide as a cholesterol-lowering agent in clinical practice. Therefore, its use for this purpose is supported by early scientific evidence, but additional well-designed human studies are necessary to establish its efficacy and safety.

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