Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Southern Prickly Ash (Zanthoxylum clavaherculis) has been used in traditional medicine systems in North America, particularly by Native American groups and later in 19th-century eclectic and herbal medicine. Historical texts and ethnobotanical records mention its use for a variety of ailments, including digestive complaints, toothache, and as a general stimulant. Its bark and berries were sometimes employed as remedies for fevers or as adjuncts in the management of gastrointestinal illnesses, including diarrhea and dysentery. However, direct historical evidence linking Southern Prickly Ash specifically to the treatment or support of cholera is limited and largely anecdotal. Some 19th-century herbal compendia and eclectic medical literature (such as King's American Dispensatory) reference its use as a "stimulant" or "tonic" during episodes of severe diarrhea or collapse, which could occur in cholera, but these recommendations are not based on controlled studies or robust clinical observation. The plant contains alkaloids and other compounds with mild antimicrobial and circulatory stimulant effects, but there is no scientific validation of efficacy against Vibrio cholerae, the causative agent of cholera. In summary, while there is some traditional precedent for the use of Southern Prickly Ash in gastrointestinal disturbances that might include symptoms similar to cholera, there is neither strong traditional emphasis nor scientific support for its use specifically in cholera.

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