Black Nightshade (Solanum nigrum) has a long history of use in traditional medicine across various cultures, including those in Asia and Africa. Its use in the support or treatment of cholera is documented in some ethnobotanical records and traditional herbal texts. In these traditions, extracts from the leaves, berries, or whole plant have been prepared as remedies for a range of gastrointestinal issues, including diarrhea and dysentery, which are symptomatic of cholera. The rationale for its use often stems from its purported anti-inflammatory and antimicrobial properties, though these claims are not specific to cholera pathogens.

However, there is a lack of robust scientific evidence or clinical trials substantiating Black Nightshade’s efficacy or safety specifically for cholera treatment. Most modern pharmacological studies have focused on other potential properties of the plant, and the available research does not directly address cholera or its causative agent, Vibrio cholerae. Furthermore, the plant contains solanine and related alkaloids, which can be toxic if consumed in large quantities.

In summary, while Black Nightshade is referenced in traditional medicine systems for gastrointestinal conditions that overlap with cholera symptoms, its use for cholera is not supported by scientific validation. Caution is warranted due to potential toxicity, and it should not be considered a substitute for medically approved cholera treatments.