Hedyotis, particularly Hedyotis diffusa (also known as Oldenlandia), is a herb commonly used in traditional Chinese medicine (TCM). While its most documented uses are for clearing heat, detoxifying the body, and as an adjunct in cancer therapy, there are references in traditional herbal compendiums to its use in treating symptoms associated with fever and chills. In TCM, chills are often seen as a manifestation of an imbalance between internal heat and cold, and herbs that "clear heat" may be prescribed to counteract such imbalances, especially if chills alternate with fever as in certain infectious or inflammatory conditions.

However, there is little to no modern scientific evidence specifically supporting the use of Hedyotis species for the treatment of chills as an isolated symptom. Most pharmacological studies have focused on its anti-inflammatory, anti-cancer, and antimicrobial properties, rather than its efficacy in alleviating chills. The use for chills is thus primarily justified by traditional practice and not by contemporary clinical trials or pharmacological research.

In summary, Hedyotis has a minor traditional basis for use in treating chills, but scientific validation for this specific indication is lacking. The evidence supporting its use for this condition is low and primarily rooted in TCM theory rather than empirical data.