Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Prickly ash (Zanthoxylum species), sometimes referred to as "mixed" when different species or plant parts are used, has a history of use in traditional herbal medicine, particularly in North America and parts of Asia. In traditional medicine, especially in Native American and Traditional Chinese Medicine (TCM), prickly ash has been used as a remedy for various conditions, including digestive complaints, poor circulation, and sometimes for symptoms interpreted as "chest pain." The rationale for its use in chest pain typically relates to its purported ability to stimulate circulation, act as a warming agent, and provide mild analgesic effects. However, there is little to no modern scientific evidence supporting its efficacy specifically for chest pain (angina or other cardiac-related pain). Clinical studies are lacking, and pharmacological research has focused more on its analgesic, antimicrobial, and circulatory effects in general, rather than on chest pain specifically. Therefore, while there is traditional justification for its use, the evidence is largely anecdotal or based on historical texts, and not validated by rigorous clinical research. The evidence rating is low due to the absence of controlled studies directly examining its effect on chest pain.

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