Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Whey protein supplementation during chemotherapy has scientific support, though the level of evidence is moderate rather than definitive. Chemotherapy often leads to side effects such as muscle wasting, malnutrition, and immunosuppression. Whey protein is a high-quality protein source rich in essential amino acids, especially leucine, which is important for muscle protein synthesis and recovery. Several clinical studies and reviews have investigated the benefits of whey protein in cancer patients undergoing chemotherapy. These studies suggest that whey protein may help maintain or improve nutritional status, preserve lean body mass, and enhance immune responses by increasing glutathione levels, a key antioxidant depleted during chemotherapy.

For example, a 2017 randomized controlled trial published in "Nutrients" showed that whey protein supplementation improved nutritional status and quality of life in cancer patients receiving chemotherapy. Another study in "Clinical Nutrition" (2019) found that whey protein, as part of a nutritional intervention, helped reduce the incidence and severity of some chemotherapy-induced side effects, such as fatigue and muscle loss. However, not all studies have found consistent benefits, and sample sizes are often small. There is a need for larger and more rigorous clinical trials to confirm these findings.

Overall, while the evidence is not overwhelming, it is sufficient to support the use of whey protein as an adjunct to standard care for reducing some side effects associated with chemotherapy, especially those related to nutrition and muscle mass preservation.

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