Evidence supporting the use of: Quercetin
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in fruits and vegetables, has been studied for its potential to alleviate side effects associated with chemotherapy. The scientific rationale comes primarily from preclinical (cell and animal) studies and a limited number of small human trials. Quercetin exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties, which may help reduce the oxidative stress and inflammation induced by chemotherapeutic agents. Some studies suggest it can protect normal cells from chemotherapy-induced toxicity while not interfering with the anticancer effects of the drugs. For example, animal studies have shown that quercetin may reduce cisplatin-induced nephrotoxicity (kidney damage) and doxorubicin-induced cardiotoxicity (heart damage). Additionally, there is some evidence that quercetin may help alleviate chemotherapy-related fatigue and gastrointestinal issues due to its anti-inflammatory effects. However, high-quality evidence in humans is still lacking. Most clinical trials are small, preliminary, or use quercetin in combination with other substances, making it difficult to isolate its effects. Furthermore, concerns remain about possible interactions between quercetin and certain chemotherapy drugs, potentially affecting their metabolism or efficacy. Leading cancer organizations do not currently recommend quercetin supplementation as a standard approach to managing chemotherapy side effects, citing insufficient evidence. In summary, while there is a scientific basis for the investigation and some promising preclinical data, robust human data is limited; thus, its use is not fully validated and should be approached with caution.

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aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
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black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
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BCAA
benzyl isothiocyanate
Caryophyllene
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