Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Amino acid and protein supplementation has some scientific support for reducing certain side effects of chemotherapy, though the evidence is moderate rather than definitive. Chemotherapy can cause significant muscle wasting, malnutrition, and compromised immune function. Amino acids such as glutamine, arginine, and branched-chain amino acids (BCAAs) have been studied for their potential to mitigate these effects. Several clinical trials and meta-analyses suggest that glutamine supplementation may help reduce the severity of oral mucositis (painful inflammation and ulceration of the mucous membranes lining the mouth) in patients undergoing chemotherapy. Similarly, protein supplementation may help maintain lean body mass and improve overall nutritional status, which is often compromised during cancer treatment. Some studies have also reported improvements in immune response and reductions in infection rates with specific amino acid supplementation. However, results are not universally positive, and the evidence varies depending on the type and dose of amino acids used, cancer type, and chemotherapy regimen. Guidelines from oncology and nutrition societies suggest that amino acid/protein supplementation may be beneficial in certain cases, but it is not universally recommended for all patients. Overall, the use of proprietary blends containing amino acids or proteins for reducing chemotherapy side effects is scientifically plausible and supported by moderate-quality evidence, but further large-scale, high-quality trials are needed to establish clear recommendations.

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