Evidence supporting the use of: Pomegranate
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pomegranate (Punica granatum) has gained interest as a supportive therapy during chemotherapy, primarily due to its rich polyphenol content and strong antioxidant properties. Several preclinical studies and a small number of clinical trials suggest that pomegranate juice or extracts may help mitigate some chemotherapy-induced side effects, particularly oxidative stress and inflammation. For example, animal models have shown that pomegranate can reduce chemotherapy-induced nephrotoxicity and hepatotoxicity, likely by decreasing oxidative damage and modulating inflammatory pathways.

Some small human studies have looked at pomegranate’s role in reducing chemotherapy-associated oral mucositis and fatigue, reporting mild beneficial effects. The proposed mechanisms involve scavenging free radicals, reducing lipid peroxidation, and supporting endogenous antioxidant enzyme systems. However, comprehensive, large-scale randomized controlled trials in cancer patients are lacking, and the evidence base is still emerging.

While pomegranate has not been a part of traditional chemotherapy support (since chemotherapy is a modern intervention), it has a long history of use in traditional medicine for general health and as a tonic. Its current use alongside chemotherapy is primarily based on scientific rationale and preliminary data, rather than traditional precedent.

Overall, while there is a modest but growing body of scientific evidence supporting the use of pomegranate to reduce certain chemotherapy side effects, more robust clinical trials are needed before it can be strongly recommended.

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Other ingredients used for Chemotherapy (reducing side effects)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acemannan
AHCC
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