Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polysaccharides, particularly those derived from medicinal mushrooms (such as β-glucans from Lentinula edodes or Ganoderma lucidum), have been researched for their immunomodulatory properties in the context of chemotherapy. Scientific studies, including randomized controlled trials and meta-analyses, suggest that certain polysaccharides can potentially reduce chemotherapy-induced side effects such as immunosuppression, fatigue, and gastrointestinal disturbances. The proposed mechanisms include stimulation of immune cell activity (e.g., macrophages, natural killer cells), modulation of cytokine production, and protection of bone marrow. For example, a meta-analysis published in PLOS One (2012) found that polysaccharide extracts from medicinal mushrooms could reduce chemotherapy-related toxicity and improve quality of life in cancer patients. However, the quality of evidence varies, with many studies limited by small sample sizes, heterogeneity in polysaccharide preparations, and methodological weaknesses. Overall, while there is scientific rationale and moderate clinical evidence supporting the adjunctive use of certain polysaccharides to mitigate chemotherapy side effects, further large-scale, high-quality studies are needed to establish efficacy and optimal dosing.

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