Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Peptides have gained some attention for their potential supportive role during chemotherapy, primarily related to their capacity to promote tissue repair, modulate immune function, and possibly reduce certain side effects such as mucositis (inflammation of the digestive tract lining). Certain bioactive peptides, like glutamine peptides, have been studied for their ability to support the integrity of the gut mucosa, which is often compromised during chemotherapy. Small clinical trials have shown that peptide supplementation may help reduce the severity and duration of oral mucositis in cancer patients receiving chemotherapy or radiotherapy. Additionally, some peptides may have mild immunomodulatory effects, potentially helping the body to better tolerate chemotherapy. However, the evidence remains preliminary. While some randomized controlled trials and mechanistic studies suggest benefit, the sample sizes are often small, and results can be inconsistent. Meta-analyses generally conclude that more robust, large-scale studies are required before routine clinical recommendation. Furthermore, not all peptides are beneficial, and some may potentially interfere with the efficacy of chemotherapeutic agents. As such, peptide supplementation during chemotherapy should only be considered under medical supervision. In summary, there is a scientific basis for exploring peptides as supportive agents during chemotherapy, particularly for mucositis, but current evidence is limited and does not yet warrant widespread clinical use.

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