Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mushrooms, particularly certain medicinal varieties such as Coriolus versicolor (Turkey Tail), Lentinula edodes (Shiitake), and Ganoderma lucidum (Reishi), have been studied for their potential to reduce chemotherapy-induced side effects. Polysaccharides, notably beta-glucans found in these mushrooms, are believed to modulate immune function. Several clinical trials, primarily in East Asia, have evaluated mushroom extracts as adjunct therapies in cancer patients undergoing chemotherapy. For example, polysaccharide-K (PSK), derived from Turkey Tail mushroom, has been shown in Japanese studies to improve quality of life, reduce fatigue, and potentially decrease the frequency or severity of chemotherapy side effects such as nausea and immunosuppression. Meta-analyses suggest moderate evidence that mushroom extracts may enhance immune cell counts and ameliorate some adverse effects, although results are not uniformly consistent and most studies use mushroom extracts rather than whole mushrooms.

While there is a tradition of medicinal mushroom use in Asia, the rating here is based on scientific validation from clinical research, mostly on specific extracts. The evidence is not overwhelming (hence a score of 3), and more high-quality, multicenter trials are needed to confirm the benefits and clarify which mushroom species and preparations are most effective. Nonetheless, current data support cautious optimism for mushrooms as supportive agents during chemotherapy.

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More about Chemotherapy (reducing side effects)

Other ingredients used for Chemotherapy (reducing side effects)

Other health conditions supported by Mushroom (unspecified)

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