Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoglobulin, a major whey protein found in bovine milk, has been investigated for its potential to support cancer patients undergoing chemotherapy by reducing side effects and improving immune function. The rationale for its use is largely based on its high cysteine content, which can serve as a precursor for glutathione synthesis. Glutathione is a critical intracellular antioxidant, and its depletion during chemotherapy is associated with increased toxicity and side effects. Several preclinical studies and small clinical trials have explored the use of whey proteins, including lactoglobulin-rich preparations, to elevate glutathione levels and enhance immune responses in cancer patients. For example, a few studies have shown that whey protein supplementation may improve antioxidant status and reduce some markers of oxidative stress in patients undergoing chemotherapy. However, the direct evidence specifically isolating lactoglobulin (as opposed to general whey protein) and its effects on chemotherapy side effects is limited. Most of the available data are from studies using mixed whey proteins rather than purified lactoglobulin. Thus, while there is a plausible scientific mechanism and some suggestive evidence, robust clinical trials confirming significant benefits for chemotherapy side effects are lacking. The overall quality of evidence remains modest (rated 2/5), and more research is needed to substantiate its specific efficacy and safety in this context.

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