Evidence supporting the use of: Human growth hormone
For the health condition: Chemotherapy (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Human Growth Hormone (HGH) has been studied as an adjunct in the management of chemotherapy-induced side effects, particularly those related to myelosuppression and cachexia (muscle wasting). Scientific research, including randomized controlled trials, has demonstrated that recombinant human growth hormone (rhGH) can stimulate hematopoiesis and support nutritional status in certain populations undergoing chemotherapy. For example, some studies suggest that rhGH may accelerate neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation, thereby potentially reducing infection risk and hospitalization duration. Additionally, HGH can promote protein synthesis and help counteract weight loss and muscle wasting, which are common in cancer patients receiving chemotherapy.
However, the evidence is mixed and context-dependent. While beneficial effects have been observed in specific scenarios, concerns about HGH potentially stimulating tumor growth due to its anabolic and proliferative effects have limited its widespread adoption. The use of HGH is not routine and is generally reserved for carefully selected patients, such as those with documented growth hormone deficiency or severe cachexia unresponsive to conventional interventions. Major clinical guidelines do not endorse the routine use of HGH for chemotherapy support, citing insufficient data on long-term safety and efficacy, particularly regarding tumor recurrence or progression risks.
In summary, there is moderate scientific evidence supporting the use of HGH in select cases to reduce certain chemotherapy side effects, but its application is limited and not standard of care. Ongoing research is needed to further clarify its role and safety profile in cancer care.
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