Evidence supporting the use of: Grape
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Grapes, particularly their skins and seeds, are rich in polyphenolic compounds such as resveratrol, quercetin, and proanthocyanidins, which have been studied for their antioxidant and anti-inflammatory properties. Some scientific studies have explored the potential of grape-derived products to mitigate the side effects of chemotherapy, including oxidative stress, mucositis, and organ toxicity. For example, animal studies have shown that grape seed extract and resveratrol may reduce chemotherapy-induced damage to organs such as the liver and kidneys, likely due to their ability to scavenge free radicals and modulate inflammatory pathways. There is also preliminary evidence in laboratory and animal models that resveratrol could protect healthy cells from some of the collateral damage caused by chemotherapy agents.

However, high-quality clinical trials in humans are limited. Some small-scale studies have suggested that oral supplementation with grape seed extract or resveratrol might reduce chemotherapy-induced mucositis or fatigue, but results are not consistent, and concerns remain regarding possible interactions between these supplements and chemotherapy drugs. For instance, resveratrol may influence the metabolism of certain chemotherapeutic agents, potentially altering their efficacy.

In summary, while there is a scientific rationale and some supportive preclinical data for the use of grape-derived products in reducing chemotherapy side effects, current clinical evidence is not robust enough to make definitive recommendations. Thus, the evidence supporting its use is rated as 2 out of 5.

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Other ingredients used for Chemotherapy (reducing side effects)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acemannan
AHCC
Alkylglycerols
Aloe vera
Alpha Glucans
Alpha lactalbumin
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
anthocyanins
Antrodia camphorata
astaxanthin
astragalus
Baikal Skullcap
BCAA
benzyl isothiocyanate
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black currant
blueberry
Boswellic Acid
branched-chain amino acids
bromelain
C-phycocyanin
cannabidiol
cannabigerol
Cannabis sativa oil
caryophyllene
chamomile
chlorella
Clostridium butyricum
Codonopsis
coenzyme Q10 (CoQ10)
coix
colostrum
curcumin
Curcuminoid
cyclodextrin
d-alpha tocopherol
dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
Glutamine
Glutathione
grape
green tea
Haematococcus pluvialis
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
HMB hydroxymethylbutyrate
Honokiol
hydroxymethylbutyrate
Hyphomycetes
L-alanyl-L-glutamine
L-carnosine
L-cysteine
L-glutamine
L-glutathione
L-glycine
L-taurine
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus lactis
Lactobacillus plantarum
Lactoferrin
lactoglobulin
Lentinan
Lentinula edodes mycelia
licorice root
lion's mane
luteolin
Marine lipid
Matcha
Melatonin
Mesima
Methylselenocysteine
Milk Protein
Milk thistle
Mistletoe
Mushroom
N-acetyl-cysteine (NAC)
Oldenlandia diffusa
Palmitoylethanolamide (PEA)
Peptides
Phenethyl isothiocyanate (PEITC)
phytocannabinoids
polysaccharides
pomegranate
probiotics
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
Saccharomyces boulardii
Saccharomyces cerevisiae
selenium
Selenomethionine
shiitake mushroom
Silychristin
soy isoflavones
spirulina
streptococcus thermophilus
Sulforaphane
Thymidine
Thymoquinone
tributyrin
Turkey tail mushroom
turmeric
Typhonium flagelliforme
Verbascoside
vitamin B6
vitamin C
vitamin E
Whey protein
Zinc