Evidence supporting the use of: Glutathione
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glutathione Use for Reducing Chemotherapy Side Effects: Scientific Evidence

Glutathione, a tripeptide with potent antioxidant properties, has been investigated for its ability to mitigate certain side effects of chemotherapy, particularly neurotoxicity and nephrotoxicity associated with agents like cisplatin and oxaliplatin. Scientific evidence supporting its use comes mainly from clinical trials and meta-analyses, although the strength and consistency of findings vary.

Several randomized controlled trials (RCTs) have demonstrated that intravenous glutathione can significantly reduce the incidence and severity of chemotherapy-induced peripheral neuropathy, especially in patients receiving platinum-based chemotherapy. For example, studies in patients with ovarian and colorectal cancer have shown improved neurological outcomes and a better quality of life with glutathione co-administration, without compromising the efficacy of the chemotherapy. Additionally, some data suggest a protective effect against cisplatin-induced kidney damage.

However, not all studies have found benefit, and clinical practice guidelines do not universally recommend its use due to variability in study designs, dosing regimens, and endpoints. The evidence is strongest for neuroprotection in platinum-based chemotherapy, but more large-scale, high-quality RCTs are needed to establish definitive recommendations. Overall, the current evidence base justifies a moderate rating, indicating scientific support but not yet routine standard of care.

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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Folinic Acid
Fucoidan
Glutamine
Glutathione
Milk Protein
Mistletoe

Products containing Glutathione

We currently have no products on Caring Sunshine that contain this ingredient.