Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cysteine, particularly in its acetylated form known as N-acetylcysteine (NAC), has been studied for its potential to reduce some side effects of chemotherapy, most notably chemotherapy-induced toxicities such as nephrotoxicity (kidney damage) caused by agents like cisplatin. The scientific rationale is based on cysteine's role as a precursor to glutathione, a critical intracellular antioxidant. Chemotherapeutic agents often induce oxidative stress, and boosting glutathione levels may help protect normal cells from damage without reducing the efficacy of the chemotherapy itself.

Clinical studies have demonstrated that NAC can reduce the incidence and severity of certain toxicities, particularly in the context of cisplatin-induced kidney damage and, to a lesser extent, neurotoxicity and ototoxicity. For example, some randomized controlled trials and meta-analyses suggest that NAC supplementation may offer some protection against nephrotoxicity when given concomitantly with cisplatin, though results are mixed and protocols vary. Importantly, there is no robust evidence that cysteine or NAC interferes with the anti-tumor efficacy of chemotherapy when used appropriately.

However, evidence for the use of plain cysteine (not NAC) is limited, and most benefits are attributed to the more bioavailable NAC form. The overall quality and consistency of the evidence are moderate, leading to a rating of 3. NAC is sometimes used clinically as an adjunct, but it is not a universal standard of care for all chemotherapy regimens or side effects.

More about Cysteine
More about Chemotherapy (reducing side effects)

Other ingredients used for Chemotherapy (reducing side effects)

Other health conditions supported by Cysteine

Products containing Cysteine