Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Coix seed (Coix lacryma-jobi), also known as Job’s tears or Yi Yi Ren in traditional Chinese medicine (TCM), has a documented history of use in East Asian herbal practices for a variety of ailments, including as an adjunct in cancer therapy. Its use alongside chemotherapy is supported by both traditional applications and a growing body of scientific literature. Preclinical studies and several clinical trials, particularly in China, have evaluated coix seed extracts—most notably Kanglaite, an injectable preparation derived from coix seed oil—for their potential to enhance chemotherapy efficacy and reduce adverse effects such as nausea, vomiting, and immunosuppression. The proposed mechanisms include immune modulation, inhibition of tumor cell proliferation, and reduction of chemotherapy-induced toxicity. Meta-analyses and systematic reviews suggest that when coix seed extracts are used in conjunction with chemo, patients may experience improved quality of life, better immune function (higher white blood cell counts), and fewer side effects, though the methodological quality of many studies varies and most research comes from China. Nonetheless, coix seed’s use is not solely traditional; there is moderate scientific validation, though larger, high-quality randomized controlled trials are needed to confirm these benefits and establish safety profiles. The evidence is strongest for injectable preparations (e.g., Kanglaite) rather than dietary coix seed. Overall, the use of coix for supporting chemotherapy and reducing its side effects is justified by both tradition and a moderate level of scientific evidence.

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Nature's Sunshine Kidney Activator TCM
Nature's Sunshine Kidney Activator (Chinese)