Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Codonopsis, also known as "Dang Shen," is traditionally used in Chinese medicine as a tonic herb, often considered a gentler alternative to ginseng. It is commonly prescribed to strengthen "qi" (vital energy), improve appetite, and support the immune system. In the context of chemotherapy, Codonopsis is traditionally believed to help alleviate fatigue, support hematopoiesis (production of blood cells), and reduce gastrointestinal side effects such as nausea and loss of appetite, which are common among cancer patients undergoing chemotherapy. Historical usage records and classical Chinese medical texts document its inclusion in herbal formulas given to individuals experiencing weakness or recovering from illness, including those with cancer.

From a scientific perspective, there are some preliminary studies—mainly in vitro and animal models—that suggest immunomodulatory, anti-fatigue, and hematopoietic effects of Codonopsis, but robust clinical evidence in human cancer patients is lacking. The majority of its use in chemotherapy support is justified by traditional practice rather than strong scientific validation. Reviews and small clinical studies sometimes mention Codonopsis as a component of multi-herb formulas, but its specific contribution and efficacy remain unclear. As such, while Codonopsis has a long history of traditional use to support patients through chemotherapy, high-quality clinical trials are needed to confirm its safety and effectiveness for this indication.

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