Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caryophyllene, a dietary cannabinoid found in various plants such as black pepper and cannabis, has attracted scientific interest for its potential to alleviate side effects associated with chemotherapy. Its primary mechanism involves activation of the cannabinoid receptor type 2 (CB2), which is linked to anti-inflammatory and analgesic effects without psychoactivity. Several preclinical studies have suggested that caryophyllene may reduce chemotherapy-induced neuropathic pain and inflammation in animal models. Additionally, some research points to its role in protecting gastrointestinal mucosa and reducing oxidative stress, which are common issues in patients undergoing chemotherapy. For example, a study published in the journal Phytotherapy Research (2014) found that caryophyllene reduced cisplatin-induced nephrotoxicity in rats, suggesting a protective effect against kidney damage. However, human clinical trials are lacking, and most findings are limited to cell culture or animal studies. There is also minimal evidence regarding its efficacy in managing nausea, vomiting, or other common chemotherapy side effects. Therefore, while the use of caryophyllene to support chemotherapy is grounded in plausible mechanisms and preclinical evidence, robust clinical validation is currently insufficient.

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