Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acemannan is a polysaccharide extracted from Aloe vera, and it has been studied for its immunomodulatory and wound-healing properties. There is limited, but emerging, scientific evidence suggesting that Acemannan may help reduce some side effects of chemotherapy, such as oral mucositis, a painful inflammation and ulceration of the mucous membranes lining the mouth. Some preclinical studies have shown that Acemannan can stimulate macrophage activity, enhance cytokine production, and promote tissue regeneration, which are beneficial for healing and immune support. Small-scale clinical trials and case reports have indicated that Aloe vera preparations containing Acemannan may reduce the severity and duration of oral mucositis in patients undergoing chemotherapy or radiotherapy. However, the quality of these studies is generally low, with small sample sizes and inconsistent methodologies. There is a lack of large, well-controlled randomized clinical trials directly assessing Acemannan’s efficacy for this purpose. Additionally, the mechanism of action is still under investigation, and the bioavailability of orally ingested Acemannan in humans is not fully established. Overall, while there is some scientific rationale and preliminary evidence for using Acemannan to alleviate certain chemotherapy side effects, the evidence base is not strong, and more rigorous research is needed to confirm its effectiveness and safety in this context.

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