Evidence supporting the use of: Vitamin A
For the health condition: Cervical Dysplasia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin A has some scientific basis for use in the management of cervical dysplasia, though the evidence is not robust and remains somewhat preliminary. Cervical dysplasia involves abnormal changes in the cells on the surface of the cervix, often associated with human papillomavirus (HPV) infection and a risk for progression to cervical cancer. Vitamin A and its derivatives (retinoids) are known to play roles in epithelial cell differentiation and immune function. Some early clinical studies and laboratory research have shown that vitamin A or retinoic acid supplementation can help normalize cervical cell growth and differentiation, potentially reversing low-grade cervical lesions (CIN 1). For example, small randomized controlled trials (RCTs) and observational studies from the 1990s and early 2000s reported regression of mild dysplastic changes with topical or oral retinoids compared to placebo. However, larger and more recent studies have failed to consistently confirm these benefits, and there is insufficient high-quality evidence to recommend vitamin A as a standard therapy for cervical dysplasia. Most guidelines do not endorse vitamin A supplementation for this purpose outside of clinical trials. Therefore, while vitamin A’s biological plausibility is supported by some early evidence, the level of scientific validation is modest, and further research is needed to establish its efficacy and safety in this context.

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