Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Indole-3-Carbinol (I3C), a compound found in cruciferous vegetables like broccoli and cabbage, has garnered scientific interest for its potential role in supporting or treating cervical dysplasia. The basis for its use is primarily scientific, with several clinical studies investigating its effects. A pivotal double-blind, placebo-controlled trial published in 2000 in Gynecologic Oncology (Wong et al.) evaluated women with cervical intraepithelial neoplasia (CIN) II and III. Participants received either placebo or I3C (200 mg or 400 mg daily) for 12 weeks. Regression of CIN occurred in 0% of the placebo group, but in 4 out of 8 (50%) of those taking 200 mg and 4 out of 9 (44%) of those taking 400 mg of I3C, suggesting a potential benefit.

Other research has demonstrated that I3C and its metabolite, diindolylmethane (DIM), modulate estrogen metabolism, promote apoptosis, and inhibit cancer cell proliferation in vitro and in animal models. These mechanisms provide a plausible rationale for its use in HPV-related cervical abnormalities. However, despite these promising findings, larger and longer-term studies are needed to confirm efficacy, determine optimal dosing, and fully assess safety. Current clinical guidelines do not recommend I3C as a standard treatment for cervical dysplasia, but it remains an area of active research. Thus, while there is scientific evidence supporting its use, the overall strength and consistency of the evidence are moderate.

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