Indole-3-carbinol (I3C) is a compound derived from cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Its use in the context of cervical dysplasia is supported by several scientific studies, though evidence remains moderate rather than definitive. The rationale for its use is based on its ability to modulate estrogen metabolism and exert anti-proliferative effects on abnormal cells. Laboratory and animal studies have demonstrated that I3C can induce cell cycle arrest and promote apoptosis (programmed cell death) in precancerous and cancerous cells of the cervix.

Clinical evidence includes a notable randomized, placebo-controlled trial published in 2000 (Wong et al., Gynecologic Oncology), in which women with cervical intraepithelial neoplasia (CIN) II-III took I3C supplements. The study found that 50% of women taking 200 mg or 400 mg of I3C daily had complete regression of CIN after 12 weeks, compared to none in the placebo group. These results suggest a potential therapeutic benefit.

However, further large-scale, long-term studies are needed to confirm these findings and to establish optimal dosing and safety. Current evidence supports the use of I3C as an adjunct, not a replacement, for conventional management of cervical dysplasia. Thus, while the basis for I3C’s use is scientific, the level of evidence is moderate (rated 3/5), reflecting promising but not yet conclusive results.