Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and cabbage. Its use in supporting or treating cervical dysplasia has scientific backing, though the evidence is moderate and not yet definitive. The interest in DIM for cervical dysplasia stems from its effects on estrogen metabolism and its potential anti-cancer properties. Several clinical studies, including randomized controlled trials, have investigated the effects of DIM supplementation in women with cervical intraepithelial neoplasia (CIN), a precursor to cervical cancer. Notably, a double-blind, placebo-controlled trial published in the British Journal of Cancer (2004) showed that oral DIM supplementation (150 mg/day) for 12 weeks led to regression of CIN 2 or 3 in a greater proportion of women compared to placebo. The hypothesized mechanisms include modulation of estrogen metabolism toward less carcinogenic pathways, induction of apoptosis in abnormal cervical cells, and inhibition of HPV (human papillomavirus) activity, which is the main risk factor for cervical dysplasia. However, while these findings are promising, other studies have yielded mixed results, and long-term safety and efficacy data are limited. Therefore, while DIM is supported by some scientific evidence for use in cervical dysplasia, it should not replace standard medical treatments or screening, and women should consult their healthcare provider before starting supplementation.

More about DIM (diindolylmethane)
More about Cervical Dysplasia

Other ingredients used for Cervical Dysplasia

Other health conditions supported by DIM (diindolylmethane)

Products containing DIM (diindolylmethane)