Evidence supporting the use of: Prebiotic (unspecified)
For the health condition: Celiac Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Prebiotics are non-digestible food components, typically fibers, that promote the growth of beneficial gut bacteria. In the context of celiac disease, which is characterized by autoimmune-mediated damage to the small intestine upon gluten ingestion, the gut microbiota is often altered or imbalanced (dysbiosis).

Some scientific studies have explored the use of prebiotics in supporting gut health in individuals with celiac disease. For example, small clinical trials and animal studies have investigated whether prebiotic supplementation (such as oligofructose-enriched inulin) can improve gut microbiota composition, increase short-chain fatty acid production, and reduce inflammation in celiac patients on a gluten-free diet. A few studies have shown modest improvements in microbiota profiles, such as increased Bifidobacteria, and enhancements in markers of gut barrier function. However, most of these studies are preliminary, with small sample sizes and short durations. There is not yet robust evidence that prebiotics significantly improve clinical outcomes or directly treat celiac disease.

Current guidelines do not recommend prebiotics as a primary or adjunctive therapy for celiac disease, but ongoing research suggests potential for supporting gut health. Overall, the evidence base is limited and somewhat promising but not definitive, warranting a rating of 2 out of 5.

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