Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the active compound in turmeric, has gained interest as a potential adjunctive therapy for Celiac Disease based primarily on its anti-inflammatory and immunomodulatory properties. Preclinical studies, particularly in animal models and in vitro experiments, have demonstrated that curcumin can reduce intestinal inflammation, protect intestinal barrier function, and modulate immune responses—mechanisms relevant to the pathophysiology of Celiac Disease. For example, a 2015 mouse study published in Phytotherapy Research showed that curcumin supplementation reduced markers of inflammation in gluten-sensitive mice. Additionally, curcumin has been shown to inhibit NF-κB activity, a key pathway involved in the inflammatory response seen in Celiac Disease. However, direct clinical evidence in humans with Celiac Disease is limited. A handful of small pilot studies and case reports suggest curcumin may help reduce symptoms or inflammatory markers, but these studies are generally of low quality, with small sample sizes and lack of placebo controls. There is also no evidence that curcumin can replace a gluten-free diet or reverse intestinal damage caused by gluten exposure. Overall, while there is some scientific rationale and preclinical evidence supporting curcumin’s use as a supportive therapy for Celiac Disease, robust clinical trials are lacking. The evidence to date supports only a cautious, adjunctive role for curcumin, and it should not be considered a primary or standalone treatment.

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Products containing curcumin

Nature's Sunshine Turmeric Curcumin (Formerly CurcuminBP)